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Pathophysiology and Mechanisms of Chronic Musculoskeletal Pain
Chronic Musculoskeletal Pain is a prevalent cause of Chronic pain with a significant economic burden. Musculoskeletal pain can be caused by repetitive strain, overuse, work-related musculoskeletal disorders, or disease conditions. It has a variety of causes which involves any condition that affects the muscles, bone, joints, connective tissue and s...
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Regenerative Therapy of Hip and Related Joints, Ligaments, and Tendons
Hip pain is a common presentation in orthopedic and interventional pain management settings. There are many causes of pain in the hip region with hip osteoarthritis being the most prevalent, affecting more than 240 million people worldwide causing significant disability and economic burden. Management of hip conditions can be challenging, given the...
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Clinical Evaluation of Safety and Efficacy of a Central cGMP Laboratory Produced Autologous Adipose-derived Stromal Vascular Fraction Cell Therapy Product for the Treatment of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a prevalent condition characterized by the progressive deterioration of the entire joint and has emerged as a prominent contributor to disability on a global scale. The nature of the disease and its impact on joint function significantly limit mobility and daily activities, highlighting its substantial influence on pati...
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The Safety and Effectiveness of Orthobiologic Injections for Discogenic Chronic Low Back Pain: A Multicenter Prospective, Crossover, Randomized Controlled Trial with 12 Months Follow-up
Background: Chronic low back pain is one of the most common causes of disability, affecting more than 600 million people worldwide with major social and economic costs. Current treatment options include conservative, surgical, and minimally invasive interventional treatment approaches. Novel therapeutic treatment options continue to develop, targe...
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Citation: Systematic Review of Platelet-Rich Plasma for Low Back Pain
Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic op...
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Osteochondral Pathologies as Effect of General Diseases
Systemic diseases can affect the osteochondral unit. Joint symptoms can be a part of the presentation in many systemic conditions and can be a manifestation of an underlying systemic condition. Musculoskeletal manifestations from systemic diseases are variable and can include arthralgia, swelling, synovitis, stiffness, joint deformities, and tendin...
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Personalized multitarget biologic injection in the spine: Prospective case series of multitarget platelet-rich plasma for low back pain
Aim: To evaluate the use of a multitarget platelet-rich plasma (PRP) injection approach for the treatment of chronic low back pain (LBP). Materials & Methods: Forty-six patients with more than 12 weeks of LBP who failed conservative treatments were injected with PRP into the facet joints, intervertebral discs, epidural space and/or paravertebral mu...
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Education and Standardization of Orthobiologics: Past, Present & future
Since the beginning of Orthobiologics, the field has continued to evolve and grow, creating a preliminary framework for clinical application in musculoskeletal injuries. With increasing demand from an aging population, and numerous physicians incorporating the techniques into their existing practice, Orthobiologics have started to develop into almo...
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Education and Understanding Orthobiologics: Then and Now
Over the past 10 years, the field of Orthobiologics has grown rapidly and started to establish a foundation as a potentially safe and efficacious alternative for a variety of musculoskeletal injuries, including joint disorders such as osteoarthritis and chronic tendinopathy. With life expectancy on the rise, and an aging population of baby boomers,...
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Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee
Objective: This study aims at evaluating the clinical effects of Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) as individual treatments for mild to moderate Osteoarthritis (OA) and it also examines the potential synergistic effects of PRP in combination with HA. Research continues to emerge examining the potential therapeutic efficacy of HA a...
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