BASIC SCIENCE
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What is Orthobiologics?
Over the past 10 years, the field of Orthobiologics has grown rapidly and started to establish a foundation as a potentially safe and efficacious alternative for a variety of musculoskeletal injuries, including joint disorders such as osteoarthritis and chronic tendinopathy. With life expectancy on the rise, and an aging population of baby boomers, the demand for viable minimally invasive options is at an all-time high...
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General Disease Effects on Musculoskeletal System
Systemic diseases can affect the osteochondral unit. Joint symptoms can be a part of the presentation in many systemic conditions and can be a manifestation of an underlying systemic condition. Musculoskeletal manifestations from systemic diseases are variable and can include arthralgia, swelling, synovitis, stiffness, joint deformities, and tendinitis...
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PLATELET RICH PLASMA (PRP)
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PRP Components Used to Promote Accelerated Healing
Platelet concentrates such as platelet-rich plasma (PRP) have gained popularity in sports medicine and orthopaedics to promote accelerated physiologic healing and return to function. Each PRP product varies depending on patient factors and the system used to generate it. Blood from some patients may fail to make PRP, and most clinicians use PRP without performing cell counts on either the blood or the preparation to confirm that the solution is truly PRP...
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Recommendations for Use of PRP
This review evaluates current clinical literature on the use of platelet-rich plasma (PRP), including leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP), in order to develop evidence-based recommendations for various musculoskeletal indications...
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Fundamental Concepts and Evidence-Based Review of PRP
Regenerative therapy involves the injection of a small volume of solution into multiple sites of painful ligament and tendon insertions (entheses) and adjacent joint spaces, with the goal of reducing pain and ostensibly promoting tissue repair and growth. Dextrose and platelet-rich plasma solutions have been shown to increase expression of growth factors in vivo and have shown promising clinical results in the treatment of tendinosus...
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Role of PRP in Tissue Regeneration
Platelet-rich plasma (PRP), an autologous derivative of whole blood that contains a supraphysiological concentration of platelets, has gained increasing attention in both the scientific literature and the wider media for its potential application in the treatment of traumatic musculoskeletal injury...
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Application of PRP to Reintroduce Healing to a Specific Site
Platelet Rich Plasma (PRP) grafting techniques are now being utilized in musculoskeletal medicine with increasing frequency and effectiveness. Soft tissue injuries treated with PRP include tendonopathy, tendonosis, acute and chronic muscle strain, muscle fibrosis, ligamentous sprains, and joint capsular laxity...
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Benefits of PRP for Muscle Strain Injuries
This review discusses the current literature regarding the use of platelet-rich plasma (PRP) in the treatment of muscle strain injuries. Case series as well as experimental trials for both human and animal models are covered...
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Benefits of PRP for Treating Adverse Effects of Steroid Injections
Triamcinolone acetonide (TA) injections are widely used to treat enthesopathy, but they may induce adverse effects such as tendon impairment and rupture. Platelet-rich plasma (PRP) is a blood fraction containing high platelet concentrations and various growth factors that play a role in tissue repair processes...
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Applications of PRP in Musculoskeletal and Sports Medicine
This article aims to provide a comprehensive review of the current literature that pertains to the therapeutic use of autologous platelet-rich plasma (PRP). The basic science literature regarding the role of growth factors in mediating the healing process and the laboratory data from in vitro and in vivo studies that evaluated PRP are reviewed...
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PRP Treatment Improving Sports Injuries
Biomedical sciences have made major advances in understanding how tissues repair, and the signalling mechanisms required to achieve this goal are progressively being dissected. Advances in the understanding of tissue repair mechanisms and the pivotal role of growth factors have stimulated the use of platelet-rich therapies by orthopaedic surgeons and sports physicians...
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PRP Treatment Improving Sports Injuries
Biomedical sciences have made major advances in understanding how tissues repair, and the signalling mechanisms required to achieve this goal are progressively being dissected. Advances in the understanding of tissue repair mechanisms and the pivotal role of growth factors have stimulated the use of platelet-rich therapies by orthopaedic surgeons and sports physicians...
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Reduced Time of Recovery from Muscle Injury with PRP
Muscle injuries represent a major part of sports injuries and are a challenging problem in traumatology. Strain injuries are the most common muscle injuries after contusions. These injuries can lead to significant pain and disability causing time to be lost to training and competition. Despite the frequency of strain injuries the treatment available is limited and is generally not sufficient to enhance muscle regeneration efficiently when fast resumption of sport activity is a primary target...
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PRP to Treat Muscle Strain Injuries
Muscle strains are one of the most common injuries treated by physicians. Standard conservative therapy for acute muscle strains usually involves short-term rest, ice, and non-steroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery...
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PRP Treatment for Chronic Tendon and Muscle Disorders in Athletes
Tendon and muscle injuries are common in elite and weekend athletes. Treatment of these injuries in both groups is rapidly evolving. Sports medicine patients are demanding better and less invasive solutions for all types of musculoskeletal disorders. In this context, platelet-rich plasma (PRP) has emerged as a potential solution. PRP is a fraction of whole blood containing concentrated growth factors and proteins. These cytokines direct tissue healing through autocrine and paracrine effects...
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MICROFRAGMENTED ADIPOSE TISSUE (MFAT) OR FAT TISSUE CELL THERAPY
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What is MFAT and what are the Clinical Applications?
Subcutaneous adipose tissue provides distinct advantages as a source of mesenchymal stem cells due to its accessibility and the ease of isolating stem cells. Human adipose stem cells, located in the stromal-vascular fraction, can be harvested using mechanical methods to produce microfragmented adipose tissue (MFAT)...
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MFAT is an Effective Long-Lasting Anti-Inflammatory Treatment
Over the last few years, human microfragmented adipose tissue (MFAT), containing significant levels of mesenchymal stromal cells (MSCs) and obtained from fat lipoaspirate (LP) through a minimal manipulation in a closed system device, has been successfully used in aesthetic medicine as well as in orthopedic and general surgery...
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MFAT to be Used as Protective Treatment Against Pain and Worsening Osteoarthritis
Adipose tissue and more specifically micro-fragmented adipose tissue (MFAT) obtained from liposuction has recently been shown to possess interesting medicinal properties whereby its application supports pain reduction and may enhance tissue regeneration particularly in osteoarthritis...
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BONE MARROW ASPIRATE CONCENTRATE (BMAC) OR BONE MARROW CELL THERAPY
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Characteristics of BMAC and a Summary on the Clinical Outcomes
Human bone marrow (BM) is a kind of source of mesenchymal stem cells (MSCs) as well as growth factors and cytokines that may aid anti-inflammation and regeneration for various tissues, including cartilage and bone. However, since MSCs in BM usually occupy only a small fraction (0.001%) of nucleated cells, bone marrow aspirate concentrate (BMAC)...
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Components of BMAC and its Uses
Bone marrow concentrate is generated by centrifugation of bone marrow aspirate. It contains mesenchymal stromal cells, anabolic chemokines/cytokines, and supraphysiological concentrations of interleukin-1 receptor antagonist protein (IL-1RA). It is an effective treatment for osteoarthritis or desmitis, or as an adjunct in surgery to enhance bone or cartilage repair...
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BMAC Provides Pain Relief for Osteoarthritis
Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors. Recent studies have reported good to excellent outcomes with the use of bone marrow aspirate concentrate (BMAC) for pain relief in the treatment of focal chondral lesions and osteoarthritis of the knee...
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SHOCKWAVE THERAPY
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What is Shockwave?
Shockwave is a rapid, short duration acoustic wave that carries energy and can propagate through tissue medium. This kind of physical force can be a mechanical stimulus that induces biological effects in living tissue. Extracorporeal shockwave therapy (ESWT) acts as a mechanical stimulus which promotes biological healing processes through a mechanotransduction...
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How Shockwave is Used to Treat Musculoskeletal Disorders
The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders...
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Instant Pain Relief with Shockwave Therapy
ESWT has been found to be useful in treating chronic musculoskeletal injuries but there was conflicting evidence regarding its efficacy in some conditions. This prospective outcome study investigates the short term effect of focal ESWT on reported pain in these patients...
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Shockwave Therapy for Relief of Delayed-Onset Muscle Soreness
To examine the effects of a single administration of focused extracorporeal shock wave therapy on eccentric exercise-induced delayed-onset muscle soreness (DOMS)...
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Decrease of Pain and Increase in Function with Shockwave Therapy
Extracorporeal shock wave therapy (ESWT) is a modern physiotherapeutic method that is useful for treating musculoskeletal conditions. There are still limited data from well-designed studies evaluating the clinical efficiency of ESWT in low back pain (LBP). Therefore, this study aimed to assess the effectiveness of the focused ESWT (fESWT) in reducing pain and improving the functional status of patients with chronic LBP...
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Use of Shockwave for Stress Fractures
Stress fractures are common painful conditions in athletes, usually associated to biomechanical overloads. Low risk stress fractures usually respond well to conservative treatments, but up to one third of the athletes may not respond, and evolve into high-risk stress fractures. Surgical stabilization may be the final treatment, but it is a highly invasive procedure with known complications...
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Using Shockwave Therapy to Improve Healing of Broken Bones
The purpose of this study was to examine the effect of focused extracorporeal shock wave therapy (ESWT) on the treatment of nonunions. As part of a prospective study, we included 143 patients (average age, 41.4 years) with a diagnosis of nonunion (mean, 14.1 months; range, 6-84 months). High-energy shock wave treatment was applied using shock wave generator...
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Surgical Alternative for Non-Healing Fractures
Fracture non-unions are still a challenging problem in orthopedics. The treatment of non-unions remains highly individualized, complex, and demanding. In most countries the surgical approach with debridement of the non-union gap, anatomical reduction and appropriate osteosynthesis along with autologous bone grafting is considered as the standard of care...
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Studies per Body Region
SHOULDER
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Indications for PRP in the Shoulder Joint and Tendons
Platelet-rich plasma (PRP) has recently been a topic of significant interest in the orthopedic community. In addition to the numerous basic science studies regarding the in vitro effects of PRP, there is more literature regarding the use of PRP in the clinical setting. PRP is overall very safe and carries minimal risk for the patient, making it appealing even if there is a small improvement in the final outcome...
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PRP Treatment for Bicipital Tendinopathy
Shoulder pain remains one of the most common complaints in the spinal cord injury (SCI) population. Several studies suggest that approximately 30–70% of people with SCI in the USA suffer from a debilitating level of shoulder pain. Often this pain is a consequence of shoulder tendinopathy resulting in impingement syndromes. Current treatment strategies include both non-operative and operative strategies, both of which have significant limitations. Given the importance for shoulder health in paraplegics using manual wheelchairs with increasing life expectancy, alternative treatments for shoulder pathology are needed...
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PRP Benefit to Rotator Cuff Tendinopathy
The purpose of this study was to evaluate the effect of subacromial platelet-rich plasma (PRP) injections in patients with refractory rotator cuff tendinopathies based on pain improvement, functional outcomes, sleep disturbances, and return to sports to the same level as before the injury...
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Improved Healing of Rotator Cuff Tendon Tear Using PRP
Rotator cuff injuries are a common source of shoulder pathology and result in an important decrease in quality of patient life. Given the frequency of these injuries, as well as the relatively poor result of surgical intervention, it is not surprising that new and innovative strategies like tissue engineering have become more appealing...
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Effectiveness of PRP for Rotator Cuff Tendinopathy
Assess platelet rich plasma (PRP) injection for rotator cuff tendinopathy (RCT)...
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PRP Stimulating Growth in Rotator Cuff Tendons with Degenerative Tears
Platelet-rich plasma (PRP) contains various growth factors and appears to have a potential to promote tendon healing, but evidence is lacking regarding its effect on human tenocytes from rotator cuff tendons with degenerative tears...
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Better results of PRP for Rotator Cuff Disease when Comparted to Dry Needling
To compare the effects of platelet-rich plasma injection with those of dry needling on shoulder pain and function in patients with rotator cuff disease...
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Therapeutic Benefits of BMAC for Rotator Cuff Tendon Tear
Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon-derived stem cells (TDSCs), but there has been no study about the effect of the BMAC-PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC-PRP on the TDSCs and to find the therapeutic effect of BMAC-PRP on the rotator cuff tendon tear...
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Enhancement of Tendon-to-Bone Healing with the Use of BMAC
To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC...
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Long-Term Alternative to Surgical Intervention for Shoulder Osteoarthritis with MFAT Treatment
We aim to show that the use of nondigested micro-fragmented adipose tissue (MFat™, Lipogems®) is a viable alternative for treatment of joint pain and inflammation associated dysfunction in shoulder osteoarthritis (OA)...
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MFAT is an Effective Treatment of Moderate-to-Sever Osteoarthritis in the Shoulder
Osteoarthritis (OA) prevalence is increased in ageing and obese populations. This prospective single-arm cohort study aimed to investigate the efficacy of autologous microfragmented adipose tissue treatment of severe knee or shoulder OA...
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Management of Calcified Rotator Cuff Tendinopathy Using Shockwave Therapy
The current trial was designed to evaluate the effects of high-energy shockwave therapy on objective and subjective outcomes among participants with calcified rotator cuff tendinopathy...
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Long Term Positive Difference in Shoulder Function Using Shockwave Therapy
This study aimed to analyze the effect of extracorporeal shock wave therapy on the shoulder function of patients with calcific tendinitis through a 12-week follow-up...
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Benefits of Shockwave Therapy for Calcific Tendinitis with a Two Year Follow Up
Shock wave therapy is a new modality that has shown efficacy in the treatment of various orthopaedic disorders...
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Improvement of Pain and Function of Shoulder with Shockwave Therapy
Calcific and noncalcific tendinitis of the shoulder can be unresponsive to conventional therapies. Extracorporeal shock-wave therapy (ESWT) has been suggested as an alternative treatment...
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Shockwave Therapy Provides Good Recovery for Bicipital Tenosynovitis
Long bicipital tenosynovitis is regarded as one of the common causes of shoulder pain and dysfunction. The traditional therapeutic approach includes a variety of conservative treatments, but these treatments are not substantiated, owing to the lack of proven clinical efficacy. Radial extracorporeal shock wave therapy (rESWT) uses a pneumatically generated and radially propagating low-energy pressure pulse and has been clinically shown to be a new alternative form of treating refractory soft tissue inflammation...
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Shockwave is an Alternative Treatment for Rotatos Cuff Tendinitis When Compared to Surgery
This study aims to investigate the efficacy of radial extracorporeal shock wave therapy (rESWT) in relieving pain and improving range of motion (ROM) and functionality besides conventional physiotherapy methods in the treatment of chronic rotator cuff calcific tendinitis (RCCT)...
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Avoiding Arthroscopic Surgery for Chronic Calcifying Tendonitis of the Shoulder with Shockwave Therapy
There are several treatment modalities for calcifying tendinitis of the shoulder. If the pain becomes chronic after several months of conservative treatment, open or arthroscopic removal is usually recommended. Recently, extracorporeal shock wave therapy has shown encouraging results in treating calcific deposits...
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ELBOW
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PRP Repair and Benefits to the Ulnar Collateral Ligament in Athletes
Platelet-rich plasma (PRP) has been shown to be effective in treating partial tears of the ulnar collateral ligament (UCL) of the elbow in overhead throwing athletes, but it is still unknown whether it has a role in complete tears. The aim of this study was to assess the effectiveness of PRP in treating complete as well as partial UCL tears...
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Pain Reduction in Recalcitrant Epicondylitis using PRP, Avoiding Surgery
Thirty patients (31 elbows) with epicondylitis unresponsive to nonsurgical treatment (including steroid injection) for >6 months received a single treatment of platelet-rich plasma injected with a peppering technique. Patients were followed using a 5-subcategory visual analog scale (VAS) for pain (0, no pain; 10, worst possible pain), modified American Shoulder and Elbow Surgeons assessment survey, and VAS for patient satisfaction (0, not at all satisfied; 10, very satisfied)...
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Double-Blind PRP versus Corticosteroid Injection with a 1-Year Follow-Up Study
Platelet-rich plasma (PRP) has shown to be a general stimulation for repair...
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Benefits of PRP vs Corticosteroid Injection into the Lateral Epicondylitis
Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages...
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PRP for Chronic Tennis Elbow: Randomized, Double-Blind Study
Elbow tenderness and pain with resisted wrist extension are common manifestations of lateral epicondylar tendinopathy, also known as tennis elbow. Previous studies have suggested platelet-rich plasma (PRP) to be a safe and effective therapy for tennis elbow...
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Benefits of PRP for Tennis Elbow
Randomized controlled trials comparing different injection therapies for lateral epicondylitis were included provided they contained data for change in pain intensity (primary outcome). Trials were assessed using the Cochrane risk of bias tool...
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Betterment of Chronic Tendinopathy with PRP Treatment
To determine whether ultrasound (US)-guided percutaneous needle tenotomy followed by a platelet-rich plasma (PRP) injection would result in pain reduction, functional improvement, or structural alterations in patients with chronic, recalcitrant tendinopathy...
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Lasting Relief of Tennis Elbow with Shockwave Therapy
Extracorporeal shockwave therapy (ESWT) is used in a number of indications in the medical field. A number of tendinopathies show good and excellent results due to evidence based medicine. The treatment of lateral epicondylitis is known to show conflicting results...
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Long Lasting Benefits of Shockwave for Tennis Elbow vs Prolotherapy
The aim of this study was to compare the efficacy of prolotherapy with hypertonic dextrose and radial shock wave therapy in chronic lateral epicondilosis...
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Continual Benefits of Shockwave Therapy for Tennis Elbow with a One Year and Two Year Follow Up
The results of both nonoperative and surgical treatments for lateral epicondylitis of the elbow have been inconsistent. Shock wave therapy has been shown to have a favorable short-term effect in treating this condition...
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Improvement of Chronic Elbow Tendinosis with PRP
One hundred forty patients with elbow epicondylar pain were evaluated in this study. All these patients were initially given a standardized physical therapy protocol and a variety of other nonoperative treatments. Twenty of these patients had significant persistent pain for a mean of 15 months (mean, 82 of 100; range, 60-100 of 100 on a visual analog pain scale), despite these interventions...
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HAND / WRIST
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STEM Cell Treatment for Wrist Problems
Stem cells are being intensively studied for their potential applications in clinical medicine. Mesenchymal stem cells (MSCs) are an important subset of stem cells which are attractive for application in musculoskeletal disorders. In this article, we review the characteristics of these MSCs that are relevant to clinical practice but that are still largely experimental in nature...
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Treatment of Carpal Tunnel Syndrome with Shockwave Therapy
Recently, extracorporeal shock wave therapy (ESWT) has been shown to be a novel therapy for carpal tunnel syndrome (CTS). However, previous studies did not examine the diverse effects of different-session ESWT for different-grades CTS. Thus, we conducted a randomized, single-blind, placebo-controlled study...
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Shockwave Therapy is Comparable with Surgical Stabilization for Scaphoid False Joint
The peculiar anatomical characteristics and precarious vascularization of the carpal scaphoid are responsible for a difficult healing of fractures and a fairly frequent subsequent evolution to pseudoarthrosis. Recently, extracorporeal shockwaves therapy (ESWT) has yielded encouraging results in the treatment of pseudoarthrosis of various bone segments...
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Decrease In Wrist Pain Using Shockwave Therapy After Carpal Tunnel Syndrome Surgery
"Pillar pain" is a relatively frequent complication after surgical release of the median nerve at the wrist. Its etiology still remains unknown although several studies highlight a neurogenic inflammation as a possible cause...
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Lower Body Regions
HIP
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Regenerative Therapy to Hip Joint
Hip pain is a common presentation in orthopedic and interventional pain management settings. There are many causes of pain in the hip region with hip osteoarthritis being the most prevalent, affecting more than 240 million people worldwide causing significant disability and economic burden...
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Improvement of Hip Modality in Dogs with MFAT and PRP Treatment
The aim of this study was to compare the efficacy and safety of a single intra-articular injection of adipose mesenchymal stem cells (aMSCs) versus plasma rich in growth factors (PRGF) as a treatment for reducing symptoms in dogs with hip osteoarthritis (OA). Methods: This was a randomized, multicenter, blinded, parallel group...
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PRP vs Hyaluronic Acid Injection for Hip Osteoarthritis
Intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) represent efficacious medical treatments for osteoarthritis (OA), although no comparative study on long-term efficacy in hip OA exists. The goals of the current study were to compare the clinical efficacy of PRP vs HA at 12 months of follow-up in patients with hip OA and evaluate the influence of the type of infiltration and patient age, sex, body mass index, and degree of OA on temporal clinical evolution...
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Improvement of Gluteus Tendinopathy use PRP
A previously published trial showed that patients with chronic gluteal tendinopathy achieved greater clinical improvement at 12 weeks when treated with a single platelet-rich plasma (PRP) injection than those treated with a single corticosteroid injection (CSI)...
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PRP Treatment for Proximal Hamstring Injuries Effectiveness
Proximal hamstring injuries can be disabling, and several traditional conservative treatments, including physiotherapy and nonsteroidal anti-inflammatory drugs, have been inconsistent. Corticosteroid injections have demonstrated success but can adversely affect local tissues. Platelet-rich plasma (PRP) has emerged as a safe, effective treatment for several orthopedic pathologies...
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Decrease in Pain with Shockwave Therapy After Pubic Overload
The incidence of groin pain in athletes is steadily increasing. Symptomatic pubic overload with groin pain and aseptic osteitis pubis represent well-known and frequently misdiagnosed overuse injuries in athletes. This study investigated the benefits of standardised non-surgical treatment for swift return-to-football...
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Shockwave Therapy as an Effective Treatment for Side Hip Pain
Greater trochanteric pain syndrome is often a manifestation of underlying gluteal tendinopathy. Extracorporeal shock wave therapy is effective in numerous types of tendinopathies...
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Shockwave Therapy has Shown More Long-Term Benefits for Greater Trochanter Pain
There are no controlled studies testing the efficacy of various nonoperative strategies for treatment of greater trochanter pain syndrome. Hypothesis The null hypothesis was that local corticosteroid injection, home training, and repetitive low-energy shock wave therapy produce equivalent outcomes 4 months from baseline...
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Regeneration Effect of Shockwave for Hip Necrosis
The effect of shockwave in osteonecrosis of the femoral head (ONFH) is poorly understood. The purpose of this study was to investigate the regeneration effects of shockwave in ONFH...
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Reducing Pain and Improvement of Mobility with Shockwave Therapy for Osteonecrosis in the Hip
Osteonecrosis (avascular necrosis) of the femoral head is a clinical disease due to a severe bone vascular alteration associated with intense pain and loss of joint function, with an incidence of 0.1% and unknown aetiology. Many classifications exist to describe it and in the final stages the patient will need a total hip arthroplasty...
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Benefits of Shockwave Therapy for Nontraumatic Hip Pain
Nontraumatic osteonecrosis of the femoral head (ONFH) is treated with a series of methods. High-energy extracorporeal shock wave therapy (ESWT) is an option with promising mid-term outcomes. The objective of this study was to determine the long-term outcomes of ESWT for ONFH...
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Shockwave Therapy is Safe and Effective for Chronic Proximal Hamstring Tendinopathy
Chronic proximal hamstring tendinopathy is an overuse syndrome that is usually managed by nonoperative methods. Shockwave therapy has proved to be effective in many tendinopathies...
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KNEE
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Benefits of PRP to Mild to Moderate knee osteoarthritis
To prospectively compare the efficacy of intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) with a sham control group (normal saline solution [NS]) for knee osteoarthritis in a randomized, dose-controlled, placebo-controlled, double-blind, triple-parallel clinical trial...
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Decrease of Pain and Increase of Function of Knee with Osteoarthritis Using PRP Treatment
Quite a few randomized controlled trials (RCTs) investigating the efficacy of platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently published. Therefore, an updated systematic review was performed to evaluate the temporal effect of PRP on knee pain and physical function...
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Positive Effect on Pain Levels and Functional Outcomes of PRP on Knee Osteoarthritis
The purpose of this meta-analysis was to compare platelet-rich plasma (PRP) and hyaluronic acid (HA) in patients with knee osteoarthritis (KOA). Methods. Randomized controlled trials (RCTs) comparing the use of PRP and HA in KOA patients were retrieved from each database from the establishment date to April 2018...
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PRP or BMAC Benefits for Knee Osteoarthritis
To systematically review the literature to compare the efficacy and safety of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and hyaluronic acid (HA) injections for the treatment of knee osteoarthritis (OA)...
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BMAC Benefits for Knee Osteoarthritis in a Randomized Controlled Trail
The purpose of this double-blind randomized controlled trial (RCT) was to compare clinical improvement and radiographic findings up to 2 years of follow-up of a single intra-articular injection of bone marrow aspirate concentrate (BMAC) versus hyaluronic acid (HA) for the treatment of knee osteoarthritis (OA)...
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4 Year Outcome of BMAC for Knee Osteoarthritis
Cell based therapies are increasingly used and results of bone marrow aspirate concentrate (BMAC) show encouraging short- to middle term results, superior to hyaluronic acid and platelet rich plasma (PRP). Most studies describe patients with mild to moderate arthritis and results of patients with KL III and IV osteoarthritis of the knee are limited to short term evaluations...
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12-Month, Blind, Placebo BMAC Study on Osteoarthritis of the Knees
Bone marrow aspiration and concentration (BMAC) is becoming a more common regenerative therapy for musculoskeletal pathology. In our current pilot study, we studied patients with mild-to-moderate bilateral knee osteoarthritis, compared pain at 12-month follow-up between BMAC-injected and saline-injected knees, and examined cartilage appearance measured by magnetic resonance imaging (MRI) T2 quantitative mapping...
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Long Lasting Therapeutic Effect of MFAT for Osteoarthritis
Stromal vascular fraction (SVF) cells and micro-fragmented adipose tissue (MFAT) have potential for treating knee osteoarthritis (OA), but their efficacy has not been compared. This study aimed to compare the clinical outcomes of SVF and MFAT for knee OA. We hypothesized that SVF provides stronger short-term effects, while MFAT offers more sustained benefits...
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MFAT Treatment can Delay the Need for Total Knee Replacement
Knee osteoarthritis (KOA) is a significant cause of disability in a globally ageing population. Knee replacement surgery has been shown to improve function and quality of life. Access to this intervention can be limited for a number of reasons including rationing of care, lack of healthcare provision in austere environments, and more recently, due to the cessation of elective orthopaedic care as a result of the COVID pandemic...
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PRP Treatment of Chronic Patellar Tendinosis
This study describes a simple, low-cost, minimally invasive way to apply PRP growth factors to chronic patellar tendinosis; 20 male athletes with a mean history of 20.7 months of pain received treatment, and outcomes were prospectively evaluated at 6 months follow-up. No severe adverse events were observed, and statistically significant improvements in all scores were recorded...
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Benefits of Shockwave for Chronic Patellar Tendinopathy
Chronic patellar tendinopathy is an overuse syndrome with pathologic changes similar to tendinopathies of the shoulder, elbow, and heel. Extracorporeal shockwave was shown effective in many tendinopathies...
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Positive Effects of PRP on Cartilage in the Knee
Platelet-rich plasma (PRP) is emerging as a biological therapy for the treatment of cartilage injuries and for intra-articular application to address knee pain. Basic science studies indicate that PRP stimulates cell proliferation and the production of cartilage matrix by chondrocytes and bone marrow–derived mesenchymal stromal cells and increases the production of hyaluronic acid by synoviocytes...
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Accelerated Cartilage Healing with PRP Treatment
The application of an autologous plasma rich in growth factors is beneficial in restoring connective tissues, as shown by clinical evidence in oral surgery and more recently in arthroscopic anterior cruciate ligament reconstruction and two cases of ruptured Achilles tendon in professional athletes...
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ANKLE
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PRP Treatment to Help Reduce Discomfort in Achilles Tendinopathy
Achilles tendinopathy [AT] is a functional problem characterised by swelling and pain above the Achilles tendon insertion region. In individuals with AT, PRP or platelet-rich plasma can be used as an alternative modality of treatment with an aim to lessen the discomfort and enhance functional recovery. We assessed the available data supporting the effectiveness of PRP in treating chronic AT...
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Treatment of Achilles Tendinopathy with PRP
The purpose of this study was to evaluate a series of patients undergoing a single platelet-rich plasma (PRP) injection for the treatment of chronic midsubstance Achilles tendinopathy, in whom conservative treatment had failed...
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Effective Treatment of Chronic Recalcitrant Achilles Teninosis Using PRP
Chronic Achilles tendinosis is a relatively common but difficult orthopedic condition to treat. In this study, autologous platelet rich plasma (PRP), a concentrated bioactive blood component rich in cytokines and growth factors, was evaluated to determine its potential long-term efficacy in treating chronic cases of Achilles tendinosis resistant to traditional nonoperative management...
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PRP Treatment for Partial Achilles Tendon Tear
Tendon injuries, especially those of the Achilles tendon, are major concerns in sports medicine. The clinical presentation can be acute or chronic and the pathologic findings can range from peritendonitis to full-thickness tendon rupture...
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Efficacy of Shockwave Therapy in Chronic Achilles Tendinopathy
Chronic Achilles tendinopathy has been described as the most common overuse injury in sports medicine. Several treatment modalities such as activity modification, heel lifts, arch supports, stretching exercises, nonsteroidal anti-inflammatories, and eccentric loading are known as standard treatment mostly without proven evidence...
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Short- and Long-Term Results of Shockwave Therapy for Achilles Tendinopathy
Earlier randomized controlled trials (RCTs) reported only midterm (3-4 months) results of extracorporeal shockwave therapy (ESWT) as a treatment for noninsertional Achilles tendinopathy (NAT)...
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Shockwave Therapy is an Effective Treatment for Shin Splints
Medial tibial stress syndrome (MTSS) is a pain syndrome along the tibial origin of the tibialis posterior or soleus muscle. Extracorporeal shock wave therapy (SWT) is effective in numerous types of insertional pain syndromes...
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PRP as Treatment for High Ankle Spain
Syndesmotic sprains are uncommon injuries that require prolonged recovery. The influence of ultrasound-guided injections of platelet-rich plasma (PRP) into the injured antero-inferior tibio-fibular ligaments (AITFL) in athletes on return to play (RTP) and dynamic stability was studied...
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FOOT
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Improvements of Plantar Fasciitis using PRP
Plantar fasciitis (PF) is the most common cause of heel pain in adults. There are numerous non-operative treatments available including platelet rich plasma (PRP) injections. PPR has demonstrated effectiveness for a range of musculoskeletal conditions including plantar fasciitis...
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Benefits of PRP for Plantar Fasciitis
Recently, platelet-rich plasma (PRP) has been used as an alternative therapy for plantar fasciitis (PF) to reduce heel pain and improve functional restoration. We evaluated the current evidence concerning the efficacy and safety of PRP as a treatment for PF compared with the efficacy and safety of steroid treatments...
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Treatment of Chronic Plantar Fasciitis with PRP
Whilst most cases of plantar fasciitis can be settled with existing conservative treatment, a few intractable cases can be difficult to resolve. New biologic treatments have been proposed for a variety of soft tissue problems...
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PRP vs Corticosteroid Injection for Chronic Severe Plantar Fasciitis
Chronic plantar fasciitis is a common orthopedic condition that can prove difficult to successfully treat. In this study, autologous platelet-rich plasma (PRP), a concentrated bioactive blood component rich in cytokines and growth factors, was compared to traditional cortisone injection in the treatment of chronic cases of plantar fasciitis resistant to traditional nonoperative management...
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PRP vs Prolotherapy for Plantar Fasciitis
To determine the efficacy of autologous platelet-rich plasma (PRP) compared with dextrose prolotherapy (DP) in patients with chronic recalcitrant plantar fasciitis (PF)..
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Shockwave Therapy vs Steroid Injection for Plantar Fasciitis
Plantar fasciitis is a self-limiting condition, but can be painful and disabling. Among the different treatments which exist, corticosteroid injections are effective and popular. Extracorporeal shock wave therapy (ESWT) is another treatment modality used for resistant conditions...
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Benefits of Shockwave for Plantar Fasciitis
Plantar fasciitis (PF) is the most common reason for heel pain. The efficacy of extracorporeal shock wave therapy (ESWT) as an ideal alternative to conservative treatments and surgery is controversial, and almost all previous articles compared general ESWT with placebo without indicating the kind of shock wave. ..
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Shockwave Therapy Reduces Pain in Ledderhose's Disease
Plantar fibromatosis is a benign disease creating nodules on the medial plantar side of affected patients. While surgical removal is regarded as the therapeutic mainstay, recurrence rates and impairment of daily activities remains substantial...
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Reduction of Pain due to Morton's Neuroma Using Shockwave Therapy
The aim of this study was to evaluate the efficacy of extracorporeal shockwave therapy (ESWT) for the treatment of Morton's neuroma by measuring changes in patient pain, function, and neuroma size...
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Spine Regions
SPINE JOINT
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PRP Injections for Facet Mediated or Modulated Pain
Facet-mediated pain is a major cause of low back pain and as a result, is a significant cause of morbidity, including disability and reduced functionality...
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Benefits of PRP outlive the Effects of Steroid Injections to the Facet Joint
To compare the effectiveness and safety between autologous platelet-rich plasma (PRP) and Local Anesthetic (LA)/corticosteroid in intra-articular injection for the treatment of lumbar facet joint syndrome...
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CERVICAL SPINE
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PRP Treatment of Early Intervertebral Disc Degeneration
Platelet-rich plasma (PRP) can stimulate intervertebral disc cell proliferation, promote extracellular matrix synthesis, and inhibit annulus fibrosus cell apoptosis. To investigate the effects of autologous PRP on the treatment of the early intervertebral disc degeneration (IDD) so as to provide the experimental basis for its clinical application...
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LUMBAR SPINE
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Comprehensive Analyses of PRP for Low Back Pain
Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine...
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Decrease in Low back Pain with PRP and BMAC Treatment
Chronic low back pain is one of the most common causes of disability, affecting more than 600 million people worldwide with major social and economic costs. Current treatment options include conservative, surgical, and minimally invasive interventional treatment approaches...
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Benefits of PRP Treatment for Treatment of Low Back Pain
To evaluate the use of a multitarget platelet-rich plasma (PRP) injection approach for the treatment of chronic low back pain (LBP). Materials & Methods: Forty-six patients with more than 12 weeks of LBP who failed conservative treatments were injected with PRP into the facet joints, intervertebral discs, epidural space and/or paravertebral muscles...
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Intradiscal PRP Injection for Low Back Pain
To determine whether single injections of autologous platelet-rich plasma (PRP) into symptomatic degenerative intervertebral disks will improve participant-reported pain and function...
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Shockwave is an Effective Treatment to Relieve Lumbar Spine Pain
Lumbar facet joints (FJ) is a common source of low back pain and contributes approximmately on one third of chronic low back pain. Medial branch radiofrequency neurotomy is considered as a gold standard in the treatment of facet joint pain. Corticosteroid injections have also presented effect in FJ pain...
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